2022

1. Covalently Engineered Protein Minibinders with Enhanced Neutralization Efficacy against Escaping SARS-CoV-2 Variants

  1. Yu Han, Zhenlin Yang, Hengrui Hu, Heng Zhang, Long Chen, Kexin Li, Linghao Kong, Qianran Wang, Bo Liu, Manli Wang*, Jian Lin*, Peng R Chen*.

  2.  Journal of the American Chemical Society    2022 6;144(13):5702-5707.

2. 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as early warning biomarkers for COVID-19 progression and myocardial injury

  1. Hangyu Chen, Xiaoxiao Li, Chao Li, Haichuan Zhu, Hongyan Hou, Bo Zhang, Liming Cheng, Hui Hu, Zhongxin Lu, Jiaxing Liu, Zeruo Yang, Lei Zhang, Nuo Xu, Long Chen, Chuan He, Chaoran Dong* , Qinggang Ge* and Jian Lin*.

  2.  Frontiers in Cell and Developmental Biology    2022 6;9:781267.

3. LDL receptor-related protein 1 (LRP1), a novel target for opening the blood-labyrinth barrier (BLB)

  1. Xi Shi , Zihao Wang, Wei Ren, Long Chen, Cong Xu, Menghua Li, Shiyong Fan, Yuru Xu, Mengbing Chen, Fanjun Zheng, Wenyuan Zhang, Xinbo Zhou, Yue Zhang, Shiwei Qiu, Liyuan Wu, Peng Zhou, Xinze Lv, Tianyu Cui, Yuehua Qiao, Hui Zhao, Weiwei Guo, Wei Chen, Song Li, Wu Zhong*, Jian Lin* and Shiming Yang*.

  2.  Signal Transduction and Targeted Therapy    2022 7:175.

4. NanoAlbumin-Prodrug Conjugates Prepared via a Thiolation-and-Conjugation Method Improve Cancer Chemotherapy and Immune Checkpoint Blockade Therapy by Promoting CD8+ T Cell Infiltration

  1. Long Chen, Nuo Xu, Pan Wang, Haichuan Zhu, Zijian Zhang, Zhanqun Yang , Wenyuan Zhang , Hongyan Guo*, Jian Lin*.

  2.  Bioengineering & Translational Medicine    2022 8:e10377.

5. 5-Hydroxymethylcytosine profiles in plasma cell-free DNA reflect molecular characteristics of diabetic kidney disease

  1. Jinlin Chu , Shujong Bi , Yao He, Ruiyao Ma, Xingyu Wan, Zihao Wang, Lei Zhang, Mengzhu Zheng, Zhanqun Yang, Lingwei Du, Yiminiguli Maimaiti, Gulinazi Biekedawulaiti, Maimaitiyasen Duolikun, Hangyu Chen, Long Chen, Linlin Li*, Lu Tie* and Jian Lin*.

  2.  Frontiers in Endocrinology    2022 29;13:910907.

2021

1. 5-hydroxymethylcytosine Profiles of cfDNA are Highly Predictive of R-CHOP treatment Response in Diffuse Large B-Cell Lymphoma Patients

  1. Hangyu Chen, Weilong Zhang, Lei Zhang, Ping Yang, Fang Li, Zeruo Yang, Jing Wang, Meng Pang, Yun Hong, Changjian Yan, Wei Li, Jia Liu, Nuo Xu, Long Chen, Xiu‑Bing Xiao, Yan Qin, Xiaohui He, Hui Liu, Haichuan Zhu, Chuan He, Jian Lin* and Hong‑Mei Jing*. 

  2.  Clinical Epigenetics    2021 13:33.

2.  Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation

  1. Heng Zhang , Yu Han , Yuanfan Yang , Feng Lin , Kexin Li , Linghao Kong, Hongxiang Liu, Yongjun Dang, Jian Lin*, Peng R Chen*.

  2.   J Am Chem Soc    2021 143(40): 16377-16382.

2020

1.  Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Nanogel as a Pro-Antigen Strategy with Enhanced Protective Immune Responses

  1. Long Chen, Bo Liu, Peng Sun, Wenjun Wang, Shiqiang Luo, Wenyuan Zhang, Yuanfan Yang, Zihao Wang, Jian Lin* and Peng R. Chen*. 

  2.  Small    2020 16, e2004237.

2.  Development of a Novel Dual-Order Protein-Based Nanodelivery Carrier That Rapidly Targets Low-Grade Gliomas with Microscopic Metastasis in Vivo

  1. Zihao Wang, Xinbo Zhou, Yuru Xu, Shiyong Fan, Ning Tian, Wenyuan Zhang, Fugeng Sheng*, Jian Lin* and Wu Zhong*.  

  2.  ACS Omega    2020 5, 20653.

3.  A Ferritin-Albumin-Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram

  1. Nuo Xu, Yuanfan Yang, Long Chen*, Jian Lin*. 

  2.  ACS Omega    2020 5(18):10415-10422.

4.  5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic and predictive biomarkers for coronary artery disease

  1. Chaoran Dong, Jiemei Chen, Jilin Zheng, Yiming Liang, Tao Yu, Yupeng Liu, Feng Gao, Jie Long, Hangyu Chen, Qianhui Zhu, Zilong He, Songnian Hu, Chuan He, Jian Lin*, Yida Tang* and Haibo Zhu*.  

  2.  Clinical Epigenetics    2020 12:17.

2019

1.  Copper-Triggered Bioorthogonal Cleavage Reactions for Reversible Protein and Cell Surface Modifications

  1. Xin Wang , Yanjun Liu, Xinyuan Fan, Jie Wang, William Shu Ching Ngai, Heng Zhang, Jiaofeng Li, Gong Zhang, Jian Lin*, Peng R Chen*.  

  2.  J Am Chem Soc    2019 141, 17133-17141.

2.  Enhancing the Effect of Pharmacological Ascorbate in Cancer Therapy via Acid-Triggered Ferritin Nanoparticles

  1. Nuo Xu, Yuan-Fan Yang, Long Chen, Liang Xu, Xiao-Jie Xu and Jian Lin*. 

  2.  Advanced Biosystems    2019 3, e1900006.

3.  Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway

  1. Dubeiqi Hong,Xuan Zhang, Riyong Li,Jiahong Yu, Yaxin Lou,Qihua He,Xuanze Li,Dong Xu, Ping Lv, Jian Lin*, Yingyu Chen*. 

  2.  Cell Death & Differentiation    2019 26, 1453-1466.

4.  A Novel Self-Assembled Mitochondria-Targeting Protein Nanoparticle Acting as Theranostic Platform for Cancer

  1. XinJie Zhu, Rifei Li , Liang Xu ,Hui Yin, Long Chen, Ye Yuan, Wu Zhong, Jian Lin *.

  2.  Small    2019 15, e1803428.

5.  Blood-Brain Barrier- and Blood-Brain Tumor Barrier-Penetrating Peptide-Derived Targeted Therapeutics for Glioma and Malignant Tumor Brain Metastases

  1. Long Chen, Dan Zeng, Nuo Xu, Chengpeng Li, Wenyuan Zhang, Xinjie Zhu, Yan Gao, Peng R. Chen, and Jian Lin*. 

  2.  ACS applied materials & interfaces    2019 11, 41889-41897.

6.  Near-infrared light and tumor microenvironment dual responsive size-switchable nanocapsules for multimodal tumor theranostics

  1. Zhiyi Wang, Yanmin Ju, Zeeshan Ali, Hui Yin, Fugeng Sheng*, Jian Lin, Baodui Wang* and  Yanglong Hou*.  

  2.  Nature Communication    2019 10, 4418.

2018

1.  Au(3)Cu tetrapod nanocrystals: highly efficient and metabolizable multimodality imaging-guided NIR-II photothermal agents

  1. Zhiyi Wang, Yanmin Ju, Shiyan Tong, Hongchen Zhang, Jian Lin, Baodui Wang*, Yanglong Hou*.  

  2.  Nanoscale Horizons    2018 3, 624-631.

2017

1.  Efficient expression of recombinant human heavy chain ferritin (FTH1) with modified peptides

  1. Jun Guo, Nuo Xu, Yao Yao, Jian Lin, Riyong Li, Jiangwei Lia*.  

  2.  Protein Expression And Purification    2017 131, 101-108.

2.  Monodisperse Au-Fe(2)C Janus Nanoparticles: An Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy

  1. Yanmin Ju, Huilin Zhang, Jing Yu, Shiyan Tong, Ning Tian, Zhiyi Wang, Xiaobai Wang, Xintai Su, Xin Chu, Jian Lin, Ya Ding, Gongjie Li, Fugeng Sheng, and Yanglong Hou*.  

  2.  ACS Nano    2017 11, 9239-9248.

2016

1.  Multistimuli-Regulated Photochemothermal Cancer Therapy Remotely Controlled via Fe5C2 Nanoparticles

  1. Jing Yu, Yanmin Ju, Lingyun Zhao, Xin Chu, Wenlong Yang, Yonglu Tian, Fugeng Sheng, Lei Zhang, Jian Lin, Fei Liu, Yunhe Dong and Yanglong Hou*.  

  2.  ACS Nano    2016 10, 159-169.

2.  Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition

  1. Liquan Gao, Chenran Zhang, Duo Gao, Hao Liu, Xinhe Yu, Jianhao Lai, Fan Wang, Jian Lin, Zhaofei Liu*.  

  2.  Theranostics    2016 6, 627-637.

2015

1.  Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20

  1. Lei Zhang, Tianhui Niu, Yafei Huang, Haichuan Zhu, Wu Zhong, Jian Lin* and Yan Zhang*.  

  2.  Scientific reports    2015 5, 12003.

2.  Structural and functional characterization of tumor suppressors TIG3 and H-REV107

  1. Hejia Wei, Lei Wang, Xiaobai Rena, Wenyu Yua, Jian Lin, Changwen Jina, Bin Xia*.  

  2.  FEBS letters    2015 589, 1179-1186.

2014

1.  Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

  1. Wu Zhong, haichuan Zhu, Fugeng sheng, Yonglu Tian, Jun Zhou, Yingyu chen, song Li* and Jian Lin*.  

  2.  Autophagy    2014 10, 1285-1300.

2.  Multifunctional Fe5C2 nanoparticles: a targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy

  1. Jing Yu ,Ce Yang ,Jingdingsha Li, Yiche Ding ,Lei Zhang ,Muhammad Zubair Yousaf, Jian Lin,Rui Pang, Lanbin Wei, Lili Xu, Fugeng Sheng*, Changhui Li, Gongjie Li, Lingyun Zhao* and Yanglong Hou*.

  2.  Advanced materials    2014 26, 4114-4120.

3.  Highly sensitive determination of copper in HeLa cell using capillary electrophoresis combined with a simple cell extraction treatment

  1. Lingchen Meng, Ziyuan Fang, Jian Lin, Meixian Li, Zhiwei Zhun*. 

  2.  Talanta    2014 121, 205-209.

2013

1.  Biosensor based on ultrasmall MoS2 nanoparticles for electrochemical detection of H2O2 released by cells at the nanomolar level

  1. Tanyuan Wang, Haichuan Zhu, Junqiao Zhuo, Zhiwei Zhu, Pagona Papakonstantinou, Gennady V Lubarsky, Jian Lin* and Meixian Li*. 

  2.  Analytical Chemistry    2013 85,10289-10295.

2.  Solution structure of monomeric human FAM96A

  1. Bingjie Ouyang, Lei Wang, Shuo Wan, Yang Luo, Lu Wang, Jian Lin, Bin Xia*. 

  2.  Journal of biomolecular NMR    2013 56, 387-392.

2012

1.  Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells

  1. Cuihong Zhou, Wu Zhong, Jun Zhou, Fugeng Sheng, Ziyuan Fang, Yue Wei, Yingyu Chen, Xiaoyan Deng* , Bin Xia, Jian Lin*.

  2.  Autophagy    2012 8,1215-1226.

2.  The heme oxygenase-1 inhibitor ZnPPIX induces non-canonical, Beclin 1-independent, autophagy through p38 MAPK pathway

  1. Cuihong Zhou, Jun Zhou, Fugeng Sheng, Haichuan Zhu, Xiaoyan Deng* , Bin Xia, Jian Lin*. 

  2.  Acta biochimica et biophysica Sinica    2012 44, 815-822.

3.  ACE-LIF method to monitor autophagy by directly detecting LC3 proteins in HeLa cells

  1. Yue Jin, Cheng Chen, Lingchen Meng, Jitao Chen, Meixian Li, Zhiwei Zhu* , Jian Lin * .

  2.  The Analyst    2012 137, 5571-5575.

4.  Guidelines for the use and interpretation of assays for monitoring autophagy

  1. Daniel J. Klionsky* , Fabio C. Abdalla, Hagai Abeliovich, Robert T. Abraham, Abraham Acevedo-Arozena, Khosrow Adeli, Lotta Agholme, Maria Agnello, Patrizia Agostinis, Julio A. Aguirre-Ghiso, Jian Lin.et al.

  2.  Autophagy    2012 8, 445-544.

5.  1H, 13C, and 15N resonance assignments of the N-terminal domain of human TIG3

  1. Lei Wang, Wenyu Yu, Xiaobai Ren, Jian Lin, Changwen Jin, Bin Xia*. 

  2.  Biomolecular NMR assignments    2012 6, 201-203.

2011

1.  An improved bimolecular fluorescence complementation tool based on superfolder green fluorescent protein

  1. JunZhou, JianLin, Cuihong Zhou, XiaoyanDeng* and BinXia*. 

  2.  Acta biochimica et biophysica Sinica    2011 43, 239-244.

2010

1.  Solution structure of the N-terminal catalytic domain of human H-REV107--a novel circular permutated NlpC/P60 domain

  1. Xiaobai Ren, Jian Lin, Changwen Jin, Bin Xia*.

  2.  FEBS letters    2010 584, 4222-4226.

2.  Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18

  1. Songhai Tian, Jian Lin, Jun Zhou, Xiaolong Wang, Yanjun Li, Xiaobai Ren, Wenyu Yu, Wu Zhong, Junhai Xiao, Fugeng Sheng, Yingyu Chen, Changwen Jin, Song Li, Zhibing Zheng* and Bin Xia*.

  2.  Autophagy    2010 6, 1032-1041.

3.  1H, 13C and 15N resonance assignments of human H-REV107 N-terminal domain. 

  1. Xiaobai Ren, Jian Lin, Changwen Jin, Bin Xia*. 

  2.  Biomolecular NMR assignments    2010 4, 175-178.